Organozymes: Molecular engineering and combinatorial selection of peptidic organo-and transition-metal catalysts
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Organozymes : Molecular engineering and combinatorial selection of peptidic organo-and transition-metal catalysts. / Meldal, Morten.
Organic Synthesis and Molecular Engineering. Wiley-Interscience, 2014. s. 333-360.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Organozymes
T2 - Molecular engineering and combinatorial selection of peptidic organo-and transition-metal catalysts
AU - Meldal, Morten
N1 - Publisher Copyright: © 2014 John Wiley & Sons, Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - There is a significant conceptual difference in the mode of action of the catalysts found in nature, that is, the enzymes, and most of the catalysts are traditionally designed and employed for organic synthesis. In recent years, a variety of peptide-based catalysts that display some of the qualities of enzyme conversions have been developed. Proline-based organocatalysts were developed by combinatorial selection from moderately active proline catalysts for the aldol family of reactions to a highly efficient peptide catalyst for selective 1,4-Michael additions. While organocatalysis with peptide-based catalysts can provide excellent activity and selectivity in biomimetic reactions, including acylations, phosphorylations, oxidations, and brominations with efficiencies approaching those of the natural enzymes, the combination of peptide templates with coordination of transition metals opens up entirely new opportunities. The peptidic nature of the catalysts described in this chapter opens up new opportunities for catalysis due to their structural resemblance with bioderived peptides.
AB - There is a significant conceptual difference in the mode of action of the catalysts found in nature, that is, the enzymes, and most of the catalysts are traditionally designed and employed for organic synthesis. In recent years, a variety of peptide-based catalysts that display some of the qualities of enzyme conversions have been developed. Proline-based organocatalysts were developed by combinatorial selection from moderately active proline catalysts for the aldol family of reactions to a highly efficient peptide catalyst for selective 1,4-Michael additions. While organocatalysis with peptide-based catalysts can provide excellent activity and selectivity in biomimetic reactions, including acylations, phosphorylations, oxidations, and brominations with efficiencies approaching those of the natural enzymes, the combination of peptide templates with coordination of transition metals opens up entirely new opportunities. The peptidic nature of the catalysts described in this chapter opens up new opportunities for catalysis due to their structural resemblance with bioderived peptides.
KW - Metal catalysts
KW - Molecular engineering
KW - Organocatalysis
KW - Organozymes
KW - Peptides
U2 - 10.1002/9781118736449.ch12
DO - 10.1002/9781118736449.ch12
M3 - Book chapter
AN - SCOPUS:85016035645
SN - 9781118150924
SP - 333
EP - 360
BT - Organic Synthesis and Molecular Engineering
PB - Wiley-Interscience
ER -
ID: 321824426